ET rank essentially captures the extent of evolutionary pressure at a given sequence position. ET-based functional annotations may also be useful to suggest protein function ( see the ET Annotation Server). In turn this can selectively block, separate, rewire, or mimic functions. These predictions can be useful for rational protein re-design and engineering since they enable researchers to efficiently target mutations to the most relevant parts of a protein. Descriptionīoth analyses are based on slightly different alignments, and can be viewed as complementary. It also suggests where one might target mutations, and which subsitutions to make in order to selectively knock out individual functional sites. A feature of the ET_report_maker is that it tries to pool information about protein sequence, structure, and elementary annotations to better interpret the ET ranks of importance of individual residues. The input is either a PDB identifier or a UniProt accession number and it returns a PDF report, plus all data files, including the. The ET report_maker runs real-value ET with hard-wired parameters.
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